RU58841 is a raw material that has not been listed and is still under development. Its use method and dosage are without scientific guidance, so we often see some people use RU58841 orally and some people use 5% or 8% RU58841 liquid.
Should we use orally or topically? We need to understand how RU58841 works first
RU58841 has a high affinity for androgen receptors located in hair follicles. By binding to these receptors, it prevents DHT and other androgens from attaching. Androgens like DHT play an important role in hair follicle miniaturization, which leads to thinning and eventually hair loss. By preventing these androgens from binding to receptors, RU58841 helps prevent or reduce hair follicle miniaturization.
For hair growth purposes, RU58841 is applied topically to the site of a burst, allowing for more precise administration using high concentrations of RU58841 directly to the hair follicle, where it effectively blocks androgen receptors and inhibits the action of dihydrotestosterone (DHT). We all know that being able to successfully inhibit DHT is the basis of male hair loss.
RU58841 is a non-steroidal anti-androgen drug that, if absorbed throughout the body, may disrupt normal hormonal balance. Limiting its effects to the scalp minimizes this risk.
From the perspective of reducing side effects, local topical use can significantly limit the amount of drug entering the blood while ensuring the effect, thereby reducing the risk of systemic side effects.
Another key factor in whether RU58841 is topical or oral is which method is more effective. Oral administration absorb through the stomach and then transport to the hair loss site through the blood, which not only increases the risk of systemic side effects, but also cannot ensure that there is enough dose to the hair loss site, thus affecting the effect. If increase the dosage blindly, there may be a huge risk of side effects.
We can directly apply RU58841 for external use to the hair loss site, the effect is direct, and limit the amount of entry into the blood, which greatly reduces the risk of side effects of the product to the user.
So if you are willing to try to study the role and effect of RU58841 in hair growth, using RU58841 liquid is the best choice.
