Ru58841 is relatively niche compared to the widely known anti-hair loss products like Minoxidil or Finasteride. Ru58841 has no overwhelming advertising, just through the user’s word of mouth, in the whole anti-hair growth market to occupy its place.
Definition of RU58841
RU58841 was studied as an anti androgen and eventually it was defined as “non-steroidal anti androgen”. And from this definition, it’s pretty intuitive to see part of what it does.
Anti androgen
“Anti-androgen” means that RU58841 can inhibit or block the action of androgens. The androgens in men are testosterone and DHT (dihydrotestosterone). After the use of RU58841, RU58841 will preferentially bind to the androgen receptor in the corresponding part, thus occupying the corresponding number of androgen receptors, so that the androgens in the body lose the opportunity to bind to these androgen receptors, so as to achieve the purpose of blocking the effect of androgen. This principle of action allows it to treat problems caused by excessive androgens such as prostate hyperplasia, prostate cancer, acne, hirsutism, and androgenic alopecia.
Although too much androgen will have certain side effects on some androgen tissues, androgen is also a necessary hormone for the body, and reducing the level of androgen in the whole body (including testosterone level and DHT level) is not acceptable. Therefore, when RU58841 acts as an anti-androgen study, its use is destined to be topical and cannot be taken orally.
Non steroidal
“Non-steroidal” is another key point in the definition of RU58841. Non-steroidal means that it is not a hormone itself and does not interfere with hormone levels in the body once it enters the body.
If the exogenous androgen enters the body, it will inevitably play a certain androgen role in the body, so that the body mistakenly thinks that the body has enough androgen levels, thereby reducing the secretion of endogenous testosterone.
If exogenous estrogen enters the body, in men, in addition to the corresponding estrogen side effects, such as emotional problems, sexual desire problems, male breast development, etc., it will also activate the negative feedback effect of HPTA(hypothalamic-pituitary-testicular axis) and reduce the release of testosterone.
Therefore, the “non-steroidal” determines the safety of RU58841, which does not interfere with its own hormone levels and brings fewer side effects.
The role of RU58841
In this article, the role of RU58841 we mentioned refers to its role in preventing hair loss. The effect of RU58841 on hair depends on the effect of the androgen DHT it antagonizes. The effect of DHT on hair is basically the root cause of all male pattern baldness, and if you don’t already know, let’s talk about it briefly.
DHT causes hair loss
There are two androgens in the male body, one is testosterone, one is DHT, why is the main cause of male hair loss DHT and not testosterone?
The source of DHT in adult males is testosterone. Testosterone is converted to DHT and also to estrogen, which is done through the action of different enzymes. In the study, it was found that when men lacked the enzyme that converts testosterone into DHT (5α reductase), they did not develop baldness. This discovery laid the foundation for the main treatment direction of male androgenic alopecia (AGA).
How does DHT cause hair loss?
Testosterone can be converted into partial estrogen under the action of enzymes, compared to testosterone, DHT does not convert estrogen at all, so DHT is also called a complete androgen.
DHT is found primarily in androgenic tissues (prostate, hair, and skin). As a result, the level of DHT in hair follicles is higher than in other non-male tissues of the body. High levels of DHT buildup can shrink hair follicles and shorten the hair growth cycle, leading to hair loss.
RU58841 anti hair loss
The principle of RU58841 treating hair loss is related to its chemical properties. It is an anti-androgen, used on the scalp, and preferentially binds to the androgen receptor in the hair follicle, so that DHT cannot bind to it, thus blocking the role of DHT, to prevent hair loss.
How does RU58841 treat hair loss?
In a trial of RU58841 to treat hair loss, scalp samples from Men with androgen-dependent alopecia were transplanted to nude mice. Hair growth in bald areas of nude mice has been shown to be inhibited after injections of testosterone.
Scalps from 20 bald men were transplanted into nude mice, kept on for eight months, and hair growth was monitored monthly for six months. All mice were topically administered testosterone (testosterone propionate, 300 micrograms in 10 microliters, 5 days a week). The 20 samples were evenly divided into two groups based on the amount of hair present on the scalp before removal.
One group was treated with RU58841 percent in ethanol and the other with the placebo ethanol.
In the placebo group, there were 28 active follicles on 10 control grafts, of which only two hair follicles (7%) started the second growth cycle.
On 10 grafts treated topically with RU58841, there were 29 active follicles, of which 8 (28%) showed a second hair cycle.
This experiment showed that low doses of RU58841 had a positive effect on hair growth. The effect of slightly higher doses of RU58841 will be described later.
The actual use effect of RU58841
Because RU58841 has not completed its clinical trials, there is no official information on its effects. The actual use effect of RU58841 is shared by users on various platforms after use, and there are a lot of shares about RU58841 on Reddit.
A share about RU58841 is a completely bald person, after using a lot of anti-hair products have no effect, his friend recommended RU58841 to him. After 35 days of use, significant improvement in the hair follicles was seen and new hair began to grow.
There are also many shares about RU58841 for hair loss that can be found on Reddit.
Advantages of RU58841 in the treatment of hair loss
Topical medicine is more targeted
The main cause of androgenic alopecia is the accumulation of excessive DHT in the scalp, and anti-hair loss products are also studied according to this target. Finasteride and Dutasteride, for example, both reduce DHT production by inhibiting the action of 5α reductase. Finasteride can reduce circulating DHT levels by approximately 70%, and dutasteride can reduce circulating DHT levels by up to 98%
But both Finasteride and Dutasteride are taken orally, and their reduction in DHT levels is systemic. DHT is a male essential androgen, completely reducing its blood level will affect men’s health, partial reduction of its level on the body to bring less impact, but the effect in the scalp area may not be very good, balding people have difficulty growing new hair.
Users of RU58841 say that using it to treat hair loss can achieve a reverse effect, and people who are completely bald will regrow their hair after treatment.
This is because RU58841 is administered topically and does not need to block the production of systemic DHT. When applied to the scalp, it will block the action of DHT in the hair follicles, so that DHT can not affect the health of the hair follicles in this area. Then, hair loss slows down. With the continuous use of RU58841, hair loss is slowed down, hair follicles in the resting period are not affected by DHT will grow new hair faster, and the overall hair density will increase. DHT causes hair to grow thinner and thinner, and without the influence of DHT, new hair will grow thicker. As a result, both the diameter of the hair and the overall density of the hair increase, and the hair looks more and healthier.
Because it does not affect DHT levels throughout the body like oral medications do, it does not cause low DHT symptoms in men, such as low libido and erection difficulties.
As a result, people who have used RU58841 say that it is more effective in treating hair loss, while experiencing no side effects.
Non steroidal with Fewer side effects
RU58841 antagonizes the effect of androgens, but it is not a hormone in itself, does not affect the level of endogenous hormones in the body, has no irritation to the skin, and has fewer side effects. In addition, it is designed to be used locally, the scope of the drug is controllable, the dosage of the drug is controllable, so that under the guidance of professional use, no side effects can be achieved.
Shorter half-life takes effect more quickly
The shorter the half-life, the faster the drug takes effect; RU58841 has a half-life of one hour. When RU58841 is applied topically, it acts quickly at the site of application, so you can see the effects of RU58841 more quickly than other anti-hair loss and growth drugs.
Because of its short half-life, after it works on the scalp, it is quickly metabolized and expelled from the body, and will no longer work in other parts of the body, further ensuring safety.
How long should I use RU58841?
When starting RU58841, use it twice a day for 3 months. Then reduce the frequency of use to once a day for another 3 months.
If there is no significant improvement in hair density after six months of continuous use, you can choose to continue to use once a day for six months.
If the total use of more than a year, the hair is still not significantly improved, it means that it is not effective for you.
If the effect is good, and the hair has been significantly improved, you can use it every 2-3 days to maintain the results obtained.
Discontinue the use of RU58841, and after 3 months, the hair will show signs of re-shedding.
The dose of RU58841
In the previous experiment with RU58841, a 1% dose of RU58841 was shown to be effective on hair. The following experiments further verified the dosage of RU58841.
In a controlled trial using four doses of 5%, 3%, 1% and 0.5%, each group was used once daily for 6 months.
After three months, four patients in the 5% group had significantly increased hair density, thickening, and length. At the fifth month, hair follicle angiography analysis revealed an average two to three times increase in the number of follicles that had increased to terminal size and initial hair growth compared to before treatment.
The 3% group only had a significant improvement in hair growth in 1 of the 5 cases, and the other 4 cases had a small effect on hair growth. Hair was less affected in the 1% and 0.5% groups.
For long-term studies, all cases in the 5% group showed progressive growth of hair and hair follicles that continued to occur for 3-7 months, and these regrown hairs remained unchanged thereafter as long as use continued.
The above experiments show that 5% of RU58841 solution is used once a day for 3 months, and the hair can be significantly improved. 3% RU58841 solution used once a day, hair growth will improve, but the improvement is not significant. If the frequency of use of 3% RU58841 solution is increased to twice a day, the use effect should be better.
Because there are not many experimental data of RU58841 that can be seen at present, according to this data, it can be concluded that its dosage is between 3%-5%, and if 3% of RU58841 solution is used, it is used twice a day. If 5% RU58841 solution is used, use once a day.
Note:3% means that the dose of 1ml per use is 30mg,5% is 50mg of RU58841 per ml.
Synergy of RU58841 and Minoxidil
Because RU58841 and Minoxidil are both topical, one would consider stacking the two on top of each other for increased effects. In fact, using them in superposition does have a certain synergistic effect and increases the progress of the treatment of baldness.
Minoxidil prevents hair loss and promotes hair growth through a variety of roles, including opening potassium channels and promoting proliferation and development of hair follicle cells; Increase vasodilator effect, bring more oxygen and nutrients to hair follicles, promote hair growth; It also shortens the hair’s resting period and prolongs the growth period. Of these known modes of action, Minoxidil does not affect DHT content in hair follicles. The accumulation of DHT in the hair follicle is one of the main causes of hair follicle atrophy and hair loss in AGA men.
So, adding RU58841 to the use of minoxidil is equivalent to your Minoxidil solution being an antagonist to DHT.
RU58841 is an effective topical drug with few side effects, it blocks the action of DHT in the hair follicles, so that the hair follicles do not shrink, hair does not thin, and does not fall out prematurely. At the same time, Minoxidil promotes the proliferation of hair follicles, and with more hair follicles, it’s possible to grow more hair. These extra hair follicles, protected by RU58841, are not affected by DHT. Minoxidil brings more nutrients to the hair follicles, helps new hair grow, and also makes existing hair healthier.
RU58841 works synergistically with Minoxidil and complements each other to prevent hair loss and accelerate hair growth.
In terms of usage and frequency, RU58841 is suitable for stacking with minoxidil. Both of them are topical, Minoxidil is used twice a day, and 3% of RU58841 is also used twice a day. Dissolve 3% of RU58841 in minoxidil solution and use it together.
If you have severe hair loss symptoms and are on a high dose of Minoxidil, you can also use 5% RU58841 with it, both of which are used once a day.
RU58841 review
Topically administered RU58841 fills the gap in oral anti-hair loss and hair growth drugs aimed at reducing DHT. It has the practical effect of slowing, stopping and reversing hair loss, and is well received by users. Topical use avoids possible systemic side effects and is safer. The short half-life allows it to reach the scalp hair follicles quickly and take effect quickly. Join forces with Minoxidil’s strong, allowing users to get double the use effect. Relying on Minoxidil’s market share, RU58841 quickly gained a place of its own.
RU58841 powder
One of the reasons RU58841 is not commercially available is because it is unstable and requires fresh mixing every week. Therefore, it is not conducive to market. In terms of actual usage, users are more likely to purchase RU58841 raw powder and then prepare their own solution or add it to minoxidil solution for use.
If you need to buy RU58841 raw powder, we are the right person to talk to. Ru58841 raw powder, we also have various anti hair loss and growth raw powders such as Minoxidil, We also have various anti hair loss and growth raw powders such as minoxidil, Finasteride, Dutasteride, CB-0301, KX-826, WAY316606, SM04554, Pyrrolidinyl Diaminopyridine, etc
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