Minoxidil powder :Widely used for AGA and FPHL 2% and 5% minoxidil solution

The first anti hair loss and growth product that people with hair loss problems come into contact with is probably Minoxidil.

Minoxidil is the most widely used drug, with a mature promotional model and already deeply ingrained in people’s hearts. In this article, we have compiled comprehensive Minoxidil information.

Research purpose of Minoxidil : treat hypertension

Although 2% and 5% Minoxidil now is best known for hair loss and hair regrowth.But do you know Minoxidil was originally used to treat severe and refractory hypertension.

It seems that hypertension and hair loss are two completely different treatment directions, but Minoxidil’s mode of action combines these two conditions, which we will explain in detail later. Minoxidil was initially developed for the treatment of hypertension, but during its use in hypertensive patients, doctors found that balding patients experienced hair regeneration and systemic hirsutism (as it was taken orally). Subsequently, it began to be used for the treatment of male androgenic alopecia (AGA), and then for the treatment of female alopecia.

How Minoxidil works in treating hair loss?

Minoxidil is the most widely used drug for treating hair loss, but its exact mechanism of action is still not fully understood. But our performance in various experiments can be glimpsed.

1. Open potassium ion channels to assist in the proliferation and development of new hair follicle cells.

Minoxidil is an effective small artery vasodilator that can open potassium channels located on the smooth muscle of peripheral arteries, leading to cell membrane hyperpolarization. Potassium ion channel activity plays a crucial role in early cell proliferation. In practical use, it has also been found that Minoxidil increases cell DNA synthesis and enhances cell proliferation. This helps to facilitate the proliferation and development of new hair follicle cells.

The vasodilation effect of Minoxidil can improve blood circulation in the scalp area, bringing more nutrients and oxygen to the scalp area, which is beneficial for the health of hair follicles and hair.

2.Minoxidil induces β- The activity of sericin stimulates hair follicle proliferation and differentiation, prolonging the growth period of dermal papilla (DP).

After normal hair loss, there will be a rest period, after which hair will grow. The hair that grows will go through a growth period, and after reaching a certain length, it will enter the shedding period again, in this cycle. Research has shown that using Minoxidil simultaneously prolongs the growth period of hair and shortens the resting period of hair, thereby extending the interval between two growth periods of human hair.

The process of Minoxidil is induced by β- It is achieved through the activity of sericin. During this process, Minoxidil also increases the size of hair follicles and the percentage of follicles in the early stages of hair growth, leading to the growth of more and thicker new hair.

In the experiment, it was observed that after treatment with Minoxidil, the capillaries around the scalp hair follicles significantly increased in the early stages of hair growth, and began to decrease in the mid to late stages of hair growth. Therefore, by prolonging the growth period of the dermal papilla, it helps to increase the capillaries around the growing hair and prolong the growth period of the hair.

Research has shown that β- Chain proteins enhance the production of prostaglandin E2 receptors, allowing hair follicles to maintain their growth phase, indirectly maintaining more hair on the scalp.

3.Minoxidil works more well through the action of sulfonyltransferase

The enzyme of Minoxidil sulfate is called sulfonyltransferase. Sulfation of compounds typically reduces the biological activity of drugs and increases their degradation, leading to drug inactivation. Minoxidil is a special case that converts it into a more biologically active drug by converting it into sulfate form.

Sulfotransferases are located in hair follicles, and the content of sulfotransferases varies among individuals. Some people have more enzymes, while others have less. Therefore, the actual effectiveness of Minoxidil varies depending on the individual.

In human scalp, there are two types of phenolsulfonyltransferases that negatively sulfate Minoxidil, and the activity of these two enzymes is also different. Patients with higher enzyme activity have a better response to local use of Minoxidil, while patients with lower sulfonyltransferase activity tend to have poorer actual usage outcomes.

Minoxidil works synergistically through known and unknown patterns to promote hair growth and reduce shedding

The scope and efficacy of Minoxidil treatment

Minoxidil is not only used to treat AGA, but also to treat various hair diseases such as alopecia areata, scar alopecia, and dry hair diseases. In addition to being used for hair, it may also improve hair growth in other parts of the body, including eyebrows and whiskers.

Minoxidil effect on AGA

Male androgenic alopecia (AGA) is a type of non scarring hair loss in which the terminal hair transforms into miniature hair. Usually, AGA is accompanied by receding hair on the forehead and thinning of the top of the head. AGA only exists in males and not in females because it is mainly influenced by the male sex hormone testosterone. In males, testosterone passes through 5- α The action of reductase converts to dihydrotestosterone (DHT). 5- α Reductases are mainly present in androgenic tissues such as the prostate, scalp, and skin.

In male AGA, all concentrations of topical Minoxidil are effective, and the average increase in hair density in males after treatment with 5% Minoxidil solution is greater than that with 2% Minoxidil solution. However, the probability of side effects such as dermatitis and hirsutism is higher.

Minoxidil effect on female type hair loss (FPHL)

The characteristic of female hair loss is a decrease in hair density on the top of the head, but the hairline on the forehead is not affected

Research has shown that all concentrations of topical Minoxidil solution are effective for female hair loss, and the average hair density of women treated with 5% Minoxidil solution increases more than that of 2% Minoxidil solution. However, the probability of side effects is higher

Minoxidil effect on alopecia areata (AA)

Alopecia areata is an autoimmune disease of hair follicles, characterized by patchy non scarring alopecia to total alopecia and systemic alopecia. Minoxinil is only effective in mild AA patients, and for severe AA patients, the use of Minoxinil alone is not effective and needs to be used in combination with other drugs.

Minoxidil effect on chronic hair loss in the resting period

Resting hair loss is an excessive shedding of hair during the resting period caused by stress events such as pregnancy, major illnesses, and surgery. Oral administration of Minoxidil can reduce hair loss.

Minoxidil effect on scar alopecia

Scar like hair loss usually presents as hair loss on the top of the head and spreads to the periphery. Minoxidil is not effective for all types of scar hair loss. Research has shown that for traction hair loss in scar hair loss, significant hair growth occurs after treatment with 2% Minoxidil alone.

Minoxidil effect on promotes eyebrow and beard growth

Topical application of Minoxidil can stimulate the growth of eyebrows and beard. Research has shown that applying 2% Minoxidil solution twice a day to eyebrows and beard areas significantly increases hair density and diameter.

How to use Minoxidil?

1.What is the different between Minoxidil solution and Minoxidil foam?

Minoxidil solution contains non active ingredients, including water, ethanol, and propylene glycol, which are used as carriers to enhance the solubility of Minoxidil. Propylene glycol is conducive to the effective delivery of drugs to hair follicles, but it may also cause local irritation, which led to the development of Minoxidil foam without propylene glycol.

The non medicinal ingredients in Minoxidil foam formula include cetyl alcohol, stearyl alcohol and butyl hydroxytoluene. Compared with Minoxidil solution, Minoxidil foam can increase the delivery of active ingredients to the target, and the drug is easy to penetrate with less irritation. Therefore, FDA has approved 5% Minoxidil foam for treatment of AGA

Minoxidil foam is more convenient to use because it dries faster and spreads to the surrounding area less.

2.How many Minoxidil should I use? Minoxidil dosage

For male AGA, the recommended dosage is 1ml of 5% Minoxidil solution or 5% Minoxidil foam with half cap twice a day.

For female hair loss, the recommended dose is 1ml of 2% Minoxidil solution or 5% Minoxidil foam with half bottle cap twice a day.

3.How about 5% minoxidil for female and 10%, 15% minoxidil for male?

After multiple experimental studies and comparisons, it was found that for female, although the effect of 5% minoxidil is slightly higher than that of 2%

Choosing 5% minoxidil is not a wise choice for its corresponding side effects.

For male, 10%, 15% more better than 5% minoxidil solution?

People always like to achieve better results by increasing the dosage, but this is not as effective in minoxidil. Although there are many 10% minoxidil solutions produced in the market to meet customer needs, multiple comparative experiments have shown that the effect of 5% minoxidil is close to that of 10%, but the number of adverse events increases significantly with more obvious side effects. So 5% minoxidil is the best choice.

4.These usage details of Minoxidil may affect your final effect

Apply Minoxidil solution to the scalp instead of the hair

Some patients have found that Minoxidil is used according to the dosage each time, but it seems to have no effect.

Check if you have applied minoxidil solution to your hair while using it, not to your scalp. Because minoxidil works specifically on the scalp when applied topically, it needs to be applied directly to the scalp by pulling out the hair.

If after using Minoxidil solution, it is found that the hair looks like it has been waxed or the hair is greasy, then it is possible that Minoxidil solution was sprayed onto the hair without actually applying it to the scalp.

For patients with longer hair, in order to avoid spraying on the hair, some tools can also be used – a medication dispenser (a container with rolling balls). The required dosage of Minoxidil solution can be poured into the dispenser, and then the medication can be directly applied to the scalp using the rolling balls, which is not a common method and does not waste.

Use fingertips to massage and absorb

Because the absorption of Minoxidil is relatively slow, if it is only sprayed on the scalp or applied casually, some effective ingredients will not be absorbed, thereby affecting the effectiveness of use.

The correct method is to start applying from the center of the affected area and gently massage with your fingertips for 3-5 minutes to help with drug absorption. This can also stimulate and reduce blood circulation, which is beneficial for improving hair loss and enhancing treatment effectiveness.

In addition to manual massage, you can also choose some massage combs, electric massagers, etc. to help with massage.

Wash hands after use

After massage absorption, be sure to wash your hands promptly and avoid touching your face or body, otherwise it is very likely to cause hair growth in other parts.

Keep the scalp clean

During medication, it is important to keep the scalp clean and dry during use.

It’s not that you need to wash your hair before each use. Overcleaning can also harm the scalp. Just maintain a normal frequency of washing your hair.

Do not wash your hair immediately after using Minoxidil

In order to achieve the best therapeutic effect of Minoxidil, it should be maintained on the scalp for at least 4 hours after use, and hair can only be washed after 4 hours.

So, avoid washing your hair, swimming, or getting wet within 4 hours of using Minoxidil.

5.The usage duration of Minoxidil

According to existing data, long-term local medication does not have serious side effects, so Minoxidil usually recommends long-term medication. If medication is stopped midway, hair loss symptoms will reappear after 3-4 months.

Generally, it takes 2-4 months to see significant results before continuing to use. The shorter the hair loss time and the smaller the area, the better the effect. So intervening in treatment at the beginning of thinning hair can have a better effect.

However, many people are concerned about the side effects of minoxidil and choose to reduce the frequency and dosage of use starting around six months to achieve the effect of reducing side effects. Reminder everyone, it is best to gradually reduce the dosage, otherwise all previous efforts may be wasted.

Minoxidil side effects

Topical use of Minoxidil is generally safe and will not cause serious side effects. However, some patients may still have corresponding side effects after use. Common side effects are mild on the skin, such as contact dermatitis (itching and scaling). Contact dermatitis is also usually related to the solution propylene glycol in Minoxidil. The use of Minoxidil solution or foam without propylene glycol can help to avoid contact dermatitis and prevent allergic reactions.

Hypertrichosis is also a possible side effect of Minoxidil, which is a symptom that is evident during the use of Minoxidil to treat hypertension. However, when Minoxidil is used to treat hypertension, it is taken orally, and when it is used to treat hair loss, it is topical. Therefore, when using Minoxidil to treat hair loss, it is not easy to develop generalized hirsutism. In the actual use process, when using higher doses of Minoxidil solution (such as 5%), it is more likely to cause hirsutism. Compared to men, women are more likely to experience symptoms of hirsutism. However, the probability of developing hirsutism with local medication is very low. Even if the medication is stopped for 1-3 months after symptoms appear, the hair on the face and arms will naturally disappear, and after 4 months, the hair on the legs will also naturally disappear.

(Fluid retention and cardiovascular effects)

The half-life of Minoxidil is about 3-4 hours, but its vasodilation effect can last up to 72 hours. Therefore, systemic (oral) Minoxidil may cause sodium and fluid retention and cardiovascular effects. Sodium and fluid retention may lead to weight gain, and congestive heart failure may occur in severe cases. However, when using Minoxidil to treat hair loss, it is topical and usually does not produce serious side effects.

No response to Minoxidil treatment – Minoxidil and Minoxidil sulfate

Minoxidil is highly effective in treating AGA hair loss, however, there are still some people who have no response to Minoxidil. This phenomenon is related to the Minoxidil sulfate mentioned earlier. Minoxinil mainly acts through minoxidil sulfate, and in this process, sulfonyltransferases are needed to actually convert Minoxinil into sulfate form. If your hair follicles do not contain sulfonyltransferase, the effect of using Minoxidil is very limited.

If you have no response to Minoxidil treatment, enzyme testing can be used to determine if it is related to sulfonyltransferase. Sulfonyltransferase exists in extracted hair follicles, and this detection method has extremely high accuracy, accurately detecting 94% of unresponsive individuals.

In the detection study of sulfonyltransferase, it was also found that in the 8th week of local minoxidil treatment, the activity of sulfonyltransferase in hair tended to shift. This finding suggests that patients who use Minoxidil effectively will not develop resistance to existing doses.

Therefore, if you use Minoxidil effectively, it will remain effective for you and will not affect the effectiveness of use due to drug tolerance.

Minoxidil and Minoxidil Sulfates

In response to the lack of sulfonyltransferase and the lack of response to Minoxidil treatment, a new formula for Minoxidil has been developed – Minoxidil sulfate solution. The use of Minoxidil sulfate can bypass the action of sulfonyltransferase, providing a new option for patients without sulfonyltransferase and those with sulfonyltransferase but low enzyme activity.

Minoxidil sulfate does provide a possibility for those who do not respond to Minoxidil, however, for individuals with normal sulfonyltransferase, normal use of Minoxidil is sufficient and there is no need to pursue Minoxidil sulfate. Due to the high molecular weight and poor permeability of Minoxidil sulfate, the actual usage effect may vary. At the same time, sulfates have poor stability in the body and are easily degraded, which is equivalent to the Minoxidil sulfate you receive. In actual use, a mixture of Minoxidil sulfate and it is used, and you do not know how much Minoxidil sulfate still accounts for in the final solution.

To improve the effectiveness of Minoxidil sulfate, high concentrations are usually required. Moreover, Minoxidil sulfate should be stored in small packaging to reduce the instability of the solution.

How to Buy Minoxidil Powder?

2% and 5% Minoxidil solutions are easy to buy anti hair loss and growth products in the market, and their safety and effectiveness have been tested in the market, so you can buy them with confidence But if you are a reseller or producer who wants to purchase minoxidil powder for production and processing purposes, it is best to choose a reputable manufacturer when choosing buy minoxidil powder suppliers, and start working with sample orders to test product quality, purity through HPLC testing, etc., to ensure that product quality meets your production needs.

If you are a person who wants to buy minoxidil powder, this is a good idea. You can adjust the formula yourself, save costs, and control the concentration, but don’t neglect product quality just to pursue low prices.

The widespread application of Minoxidil also indicates that its actual demand is very large. We offer a large quantity of high-quality Minoxidil raw powder, offering greater price advantages on top of high quality to help you reduce costs.

In addition to Minoxidil and Minoxidil sulfate, we also have various anti hair loss and growth raw powders such as RU58841, Finasteride, Dutasteride, CB-0301, KX-826, WAY316606, SM04554, Pyrrolidinyl Diaminopyridine, etc

If you have any questions, please feel free to contact me.