Common minoxidil combination

Here is the minoxidil combination use for the condition of male hormone alopecia.

1. The most common and effective combination is minoxidil + finasteride

Minoxidil stimulates hair follicles and prolongs the growth phase of the hair cycle, which can lead to hair growth and increased thickness. The usual dose is 1ml of 5% minoxidil solution twice a day

Finasteride inhibits 5-alpha reductase, which converts testosterone to dihydrotestosterone (DHT). Reducing DHT levels helps prevent hair follicle miniaturization, slows hair loss, and may regrow hair. The dosage is 1mg/day, once a day, preferably at the same time every day.

The two products are used in combination, usually in 3-6 months will show results, 12 months when the effect is the best state. Most people need continuous use to achieve results, but many people do not need continuous use because of side effects. The best state is to gradually reduce the dose used when the effect is optimal, and finally achieve the purpose of stopping the drug.

Because male hormone levels are not always high in the body and usually decrease gradually after the age of 25-30, you don’t really need to take it long-term.

2. Minoxidil solution plus RU58841 solution

RU58841 works by blocking androgen receptors in hair follicles, preventing dihydrotestosterone (DHT) from binding to them. This helps reduce DHT-induced hair follicle miniaturization, which is a major cause of androgenic alopecia.

When combined with minoxidil, which promotes hair growth, and finasteride, which reduces DHT production, RU58841 may target hair loss through a variety of mechanisms, thereby improving the overall efficacy of hair loss treatment.

The combination of RU58841 and minoxidil is usually used in two ways

Pre-mixed solution: Some users mix the RU58841 solution directly with the minoxidil solution.

The usual concentration is 5% minoxidil and 5% RU58841. The dosage used is usually the same as minoxidil alone (1 ml or half covered foam).

We have to use the two separately: use RU58841 and minoxidil separately, with enough time between applications and let the scalp absorbe them.

What are the side effects of the minoxidil combination?

The first is scalp irritation: Some users may experience redness, itching, or irritation at the application site, especially when using RU58841 in combination with minoxidil. When made them into solutions, add with solvents, such as ethanol PEG, etc., which can irritate the skin.

Side effects similar to minoxidil dryness: aggravated when combined.

Because RU58841 is a non-steroidal anti-androgen drug, it is mainly used to treat androgenic alopecia. It is often used in combination with minoxidil and finasteride in experiments, although it is not approved by the U.S. Food and Drug Administration and has limited long-term safety data. Therefore, it is best to perform a patch test before use to check for allergic reactions or skin sensitivity. Avoid more serious allergic reactions, such as skin itching, ulceration, overirritation, etc.

3. Minoxidil and Low intensity Laser Therapy (LLLT) 

LLLT is a non-invasive treatment that uses a laser to stimulate hair follicles and promote hair growth.

For men and women with androgenic alopecia who are looking for a non-medical way to promote hair growth in conjunction with minoxidil.

4. Minoxidil and platelet-rich plasma (PRP) therapy

PRP therapy: involves injecting concentrated platelets from the patient’s own blood into the scalp to promote healing and hair growth.

For people who suffer from various types of hair loss, including androgenic alopecia and alopecia areata, seeking regenerative treatments to promote hair growth.

We all know that FDA approved minoxidil to treat hair loss, but who is suitable for minoxidil treatment? Minoxidil is for androgenic alopecia, commonly referred to as male or female pattern hair loss. This condition is characterized by a gradual thinning of the hair on the scalp that usually follows a predictable pattern. Minoxidil works by lengthening the growth period of hair and enlarging small hair follicles, thereby increasing hair density and thickness.

While minoxidil is most effective for androgenic alopecia, it has limited effectiveness for other types of hair loss, such as:

Alopecia areata: An autoimmune disease that causes patchy hair loss.

Primary hair loss: Due to stress, illness, or hormones

The root cause of alopecia areata and primary hair loss is not the cause of male hormones in the body, so minoxidil can work by lengthening the hair growth period and enlarging small hair follicles, but it is mainly the right drugs that target the cause to eradicate it.